Özet:

Purpose: In the study, in patients aged 65 and older with single-focus glioblastome multiforme chemoradiotherapy, the gross total recession of the primary tumor was applied and not applied in the groups compared the reactions to chemoradiotherapy and survivors. Methods and methods: Patients aged 65 and older with histologically proven glioblastome multiforme diagnosis have been evaluated as retrospective. Those who have completed radiotherapy therapy simultaneously with themosolamide in patients who have been applied and not applied with Gross total resection have been analyzed in terms of therapeutic responses, progressive survival, unrecurrent survival and general survival. Results: 55 patients were included in the study. The overall response ratio was similar in both groups observed by 23.5% vs. 23.8%, p=0.984. In both groups, median overall survival was 13 months while p=0,645; gross total resection applied in the arm median unrecurrent survival 8 months; gross total resection applied in the group median unprogressive survival was 6 months. The median tumor diameter in both groups was 4 cm p=0,875 . The rate of patients who could receive recurrence or post-progressive rescue treatment was similar. In the univariate analysis, gender HR 1,061 [95CI 0,589-1,912]; p=0,844 , age HR 0,992 [95CI 0,538-1,831]; p=0,980 , tumor diameter HR 0,740 [95CI 0,411-1,333]; p=0,316 , primary gross total resection HR 0,869 [95CI 0,470-1,607]; p=0,653 was not effective on overall survival, while left brain tumors HR 2,183 [95CI 1,204-3,957]; p=0,010 general survival was followed longer. Results: Sixteen-five years old and older single-centric glioblastoma multiforme patients with gross total recession and non-applicated groups have not observed differences in response and overall survival differences

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