Abstract:

Non-Hodgkin’s lymphomas are a heterogeneous malignancy group originating from lymphoid tissue and having an increasing frequency in the world in the last decade. Its clinic and response to treatment vary according to different sub-types. Today, the most compelling situation for a clinician is the patients with relapsed or refractory Non-Hodgkin’s lymphoma. Its prognosis is poor even despite different treatments and autologous stem cell transplantation. The aim of the present study is to present the experiences in the diagnosis of relapsed/refractory Non-Hodgkin’s lymphoma to the literature. A total of 193 patients, who were diagnosed and treated at Sivas Cumhuriyet University Medical Faculty Hospital between 2011 and 2021 were included in the study. 145 of these patients were not relapsed/refractory and 48 were relapsed/refractory. Rescue therapy was provided to the relapsed/refractory patients; however, autologous stem cell transplantation could only be applied to 25 patients. Of the stem cell transplantation patients, 17 are still alive. As a result, the best treatment under current conditions is the rescue therapy, followed by autologous stem cell transplantation. However, relapsed/refractory Non-Hodgkin’s lymphomas have a quite poor prognosis; thus, new treatment agents are required.

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