Özet:

We aimed to determine the risk factors for brain metastases among patients with advanced NSCLC. Aretrospective analysis was made for 163 advanced NSCLC patients. The patients were registered intotwo groups in terms of who developed brain metastases or not during follow-up. Age, gender, performance status, weight-loss, histopathologic type, localisation of the primary tumor, smokingstatus, response to treatment, and lactate dehydrogenase (LDH), albumin, heamoglobin levels at thetime of the diagnosis were analyzed by univariate and multivariate analysis. Cox proportional hazardmodel and Kaplan-Meier survival analysis.There were 40 (24.5%) patients who had brain metastasesat the follow-up. Risk factors for brain metastases were weight-loss, extracranial metastases, upperlocalisation of primary tumor, unresponsiveness of first-line chemotherapy regime, mediastinal lymphnode involvement and high LDH level. Median survival was 44 weeks, overall survival rate at 1 yearwas 38%, median time to onset of brain metastases was 32 weeks and median survival from thediagnosis of brain metastases was 28 weeks. Weight-loss, extracranial metastases, upper localisationof primary tumor, unresponsiveness of first-line chemotherapy regime, high LDH level and mediastinal lymph nod involvement were the most important risk factors for the prediction of brain metastases. Prophylactic cranial irradiation may be chosen in those patients to delay brain relapse, functionprove quality of life and to decrease morbidity and mortality of brain metastases.

Anahtar Kelimeler: