Objective: Interleukin-6 (IL-6) plays a role in pathways in inflammation and angiogenesis in tumor formation. C-reactive protein (CRP) is a marker of inflamation and accompanies the progression of many cancers.In this study, the effect of preoperative CRP and IL-6 levels on the prognosis of patients with gastric cancer was investigated. Materials and Methods: Forty-five patients who underwent elective surgery for gastric cancer in our clinic between January 2002 and April 2004 were included in the study. Demographic, histopathological and clinical characteristics of the patients were evaluated. CRP and IL-6 levels were measured in preoperative blood samples. Results: IL-6 levels were significantly correlated with preoperative metastasis, mortality, and CRP levels. Factors affecting CRP levels were preoperative and postoperative metastasis, mortality, CEA, and IL-6. Multivariate analysis showed that CRP elevation increased IL-6 levels independently of other factors. Factors affecting disease-free survival were; CA 19-9, IL-6, CRP, differentiation, tumor stage, Lauren classification, and presence of preoperative metastasis. Factors affecting total survival were; IL-6, CRP, CEA elevation, differentiation, stage, wall invasion thickness, presence of diffuse type in Lauren classification, presence of lymphatic invasion, presence of preoperative metastasis, and chemotherapy treatment. Conclusion: Measurement of preoperative serum CRP and IL-6 levels in gastric cancer reflects the malignant potential and progression of the disease. Therefore, they can be used as useful tumor markers in monitoring patients and monitoring their response to treatment.
Objective: Interleukin-6 (IL-6) plays a role in pathways in inflammation and angiogenesis in tumor formation. C-reactive protein (CRP) is a marker of inflammation and accompanies the progression of many cancers.In this study, the effect of preoperative CRP and IL-6 levels on the prognosis of patients with stomach cancer was investigated. Materials and Methods: Forty-five patients who underwent elective surgery for stomach cancer in our clinic between January 2002 and April 2004 were included in the study. Demographic, histopathological and clinical characteristics of the patients were evaluated. CRP and IL-6 levels were measured in preoperative blood samples. Results: IL-6 levels were significantly correlated with preoperative metastasis, mortality, and CRP levels. Factors affecting CRP levels were preoperative and postoperative metastasis, mortality, CEA, and IL-6. Multivariate analysis showed that CRP elevation increased IL-6 levels independently of other factors. Factors affecting disease-free survival were; CA 19-9, IL-6, CRP, differentiation, tumor stage, Lauren classification, and presence of preoperative metastasis. Factors affecting total survival were; IL-6, CRP, CEA elevation, differentiation, stage, wall invasion thickness, presence of diffuse type in Lauren classification, presence of lymphatic invasion, presence of preoperative metastasis, and chemotherapy treatment. Conclusion: Measurement of preoperative serum CRP and IL-6 levels in stomach cancer reflects the malignant potential and progression of the disease. Therefore, they can be used as useful tumor markers in monitoring patients and monitoring their response to treatment.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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