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Background and Aim: Mental health is one of the most important issues in the field of health and wellness that is of special importance to nurses in maintaining the health of patients due to their occupational nature. Therefore, the aim of this study was to compare the effectiveness of mindfulness training and cognitive-behavioral therapy on nurses' mental health in coronavirus epidemics. Methods: The present study is applied in terms of purpose and semi-experimental in terms of method with pre-test design and post-test with control group. The statistical population of this study included all nurses working in hospitals in Tehran in 1400 that 45 people were selected by available sampling method and one group waiting for treatment and two experimental groups (15 people in each group) were randomly replaced. . One experimental group received 8 90-minute sessions with mindfulness method and one experimental group received 8 90-minute sessions with cognitive-behavioral therapy and the waiting group did not receive any training. The groups completed the Mental Health Questionnaire (GHQ-28) as a pretest and posttest. Analysis of covariance was used to analyze the data. Results: The results showed that the mean score of mental health in the mindfulness experimental group and in the experimental cognitive-behavioral therapy group was significantly different (p <0.01) and this rate was not significantly different in the control group. Conclusion: The findings of this study recognize the importance of the use of mindfulness therapy and cognitive behavioral therapy in increasing and improving the mental health of nurses. These two approaches can be used to improve the level of occupational health of nurses and provide optimal health services in hospitals.

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