Özet:

Introduction: In this study, we examined the methicillin resistance and antibiotic susceptibility patterns of staphylococcus isolates from various clinical specimens. Materials and Methods: Between 2010 and 2015 in our hospital, 21478 staphylococci strains (6317 S. aureus strains and 15161 CNS strains) isolated from various clinical specimens of patients were included in the study. Results: In our study, 6317 (29.4%) strains were Staphylococcus aureus (S. aureus) and 15161 (70.6%) strains were coagulase-negative staphylococcus (CNS) strains. The resistance rates to methicillin was significantly higher in CNS strains than in S. aureus strains (p<0.001). A significant decrease in the methicillin resistance rates of S.aureus strains was found over the years (p<0.001). The methicillin resistance ratios in S.aureus strains and CNS strains were 4.5% and 32.1% in outpatients, 14.5% and 47.4% in general services, 27.7% and 51.8% in intensive care units (ICU), respectively. In both S. aureus and CNS strains, methicillin resistance rate was found to be higher in strains isolated from ICU than general services (p<0.001, p<0.001). Conclusion: The declining rates of methicillin resistance in staphylococci are encouraging, however this condition should be maintained in the longer term. We believe that we can continue to reduce in the rate of resistance by rational use of antibiotics and implementation of infection control measures.

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