Özet:

Lung cancer is the most common reason of cancer mortality all over the world. Although smoking is the most important factor in lung cancer etiology, additionally, environmental, genetic and occupational factors also contribute to this disease. Despite the fact that there have been progress in lung cancer area in terms of treatments, it has still poor prognosis. Lung cancer is generally classified into two major histological types; small cell lung cancer and non-small cell lung cancer. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases of lung cancer. Epithelial growth factor receptor mutations are among the most common mutations in NSCLC. These mutations are more prevalent in lung cancer patients who are non-smokers, female, and of Asian ethnicity and tumors which have these mutations response better to tyrosine kinase inhibitors in NSCLC. In this review, the prognostic and predictive role of EGFR will be evaluated in NSCLC. Key words: Non-small cell lung cancer, epidermal growth factor receptor, tyrosine kinase inhibitors

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