Özet:

Objective: Tumor-associated tissue eosinophilia (TATE) has been noted in human cancers, sometimes with dif­ferent results regarding their association with clinical out­come. In this study, the association between TATE and prognostic parameters of supraglottic laryngeal cancer was analyzed. Materials and methods: Sixty-two patients with diagno­sis of supraglottic laryngeal squamous cell carcinoma and who treated surgically in our center were evaluated. The cases were divided into 3 categories according to the av­erage number of eosinophils per high-power field (400x): 0 (negative), 1-5 (grade 1+), more than 5 (grade 2+). Results: We found 24 TATE-negative (38.7%) and 38 TATE-positive (61.3%) cases. There was not any statisti­cally significant correlation between TATE and tumor dif­ferentiation, vascular invasion, perineural invasion, lymph node metastasis, patients\' ages, T stages (p>0.05). As expected, vascular invasion correlated with lymph node metastasis (p=0.001). Conclusion: The results of this study showed that TATE has no correlation with prognostic parameters such as histologic differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients\' ages and T stages in supraglottic laryngeal squamous cell carcino­ma. The data suggest that stromal eosinophilic infiltration is not useful for determining biological aggressiveness in supraglottic laryngeal cancer.

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