Özet:

Objectives: We aimed to compare the effects of fixed combinations of dorzolamide/timolol maleate (DTFC) and la-tanoprost/timolol maleate (LTFC) at primary open angle glaucoma patients and assess the patient compliance to treatment. Materials and Methods: Forty-four eyes of 24 patients taking LTFC, 35 eyes of 24 patients taking DTFC and totally 79 eyes of 48 patients were included in this study. Patients were followed for 6 months. At 3rd month, diurnal in-traocular pressure (IOP) fluctuations were assessed. Perimetry and retinal nerve fiber layer (RNFL) analyze were repeated at 6th month. Results: Both medicines had efficiently controlled the IOP and diurnal fluctuations and statistically no significant dif-ference was observed (p>0.05). Perimetric and RNFL measurements were not different in both groups(p>0.05).When we have compared the results of baseline and 6th months, MD and sLV values decreased, RNFL in some cases in-creased on the other hand we have also observed a decrease in some cases(p0.05). Most of the patients did not forget to take their medicines (DTSK %54.2 and LTSK %66.7) and in following visits, compliance and adherence were improved in both groups. It is detected that duration of medi-cine use may affect the compliance (p=0.007). Conclusion: It is observed that two medicines controlled the IOP and diurnal fluctuations clinically efficient and effec-tively, had reasonable side effects and had high patient compliance to treatment.

Anahtar Kelimeler: