Özet:

Introduction : Characterized by tendency for delayed recurrences and good prognosis mostly, granulosa cell tumors represent the most common sex-cord stromal tumors of the ovary and form 2-3% of all ovarian cancers. Clinically, they are well-known for their potent estrogenic capacity and postmenopausal bleeding constitutes its most common clinical sign, which usually ensues following the prolonged exposure of the endometrium to estrogen released from the tumor. Therefore, estrogen-related endometrial anomalies are frequently encountered in patients with granulosa cell tumors. In this study we aimed to present the patients with granulosa cell tumors operated in our institution and to evaluate their endometrial findings in the light of a literature review. Material and methods: Endometrial findings of the patients who had been operated in the Obstetrics and Gynecology Department of Zeynep Kamil Training and Research Hospital were retrospectively analyzed. The pathological specimens belonging to the individual cases were re-evaluated and changes in the endometrium were noted. Endometrial findings were classified as endometrial cancer, endometrial hyperplasia (complex with/without atypia, simple with/without atypia), endometrial polyp, irregular proliferative endometrial layer and non-significant findings. Results: The analysis of 29 endometrial specimens has revealed endometrial polyp in 8 cases, irregular proliferative endometrium in 3 patients, endometrial hyperplasia in 7 cases and endometrioid adenocarcinoma in one patient. Among the patients diagnosed with endometrial hyperplasia 2 patients had complex endometrial hyperplasia with atypia, one had complex endometrial hyperplasia without atypia and 4 patients had simple endometrial hyperplasia without atypia. Neither the tumor differentiation grades nor the tumor diameters have demonstrated a correlation with the endometrial findings. Conclusion: Granulosa cell tumors are hormonally active, therefore they can give rise to endometrial pathologies leading to secondary symptoms and findings. Therefore when an adnexial mass is detected and a granulosa cell tumor is suspected, the evaluation of the patient should be extended for all endometrial pathologies

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