Abstract:

The aim of the study was to evaluate anticancer activity of the methanol and aqueous extracts of leaves of Tinosporacordifolia Wild Miers against a Human Breast Carcinoma Cell line(MDAMB231) by MTT assay. The coarse powder of leaf were subjected to Soxhletextraction and microwave assisted extraction using methanol and water as solvent. The IC50 values of aqueous extract of leaf followed by soxhlation and methanol extract of leaf by microwave extraction were found to be 59.85μg/mL and 249μg/mLrespectively in MDAMB231 cells in comparison to Standard Vincristine 14.41µM whereas methanol extract of leaf by soxhlet and aqueous extract by microwave extraction did not possess any anticancer activity. This study suggests that Tinosporacordifolia can be useful in the treatment of breast cancer.

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