Özet:

Purpose: The purpose of our research is to determine the genotype frequencies of Ala16Val polymorphism in persons with coronary arterial disease (KAH) of the manganese hyperoxide dismutaz (MnSOD) gene and to evaluate the interaction with genotype-heart and cardiovascular disease and genotype-biochemical parameters and serum MnSOD activity. Tools and methods: MnSOD gene Ala16Val genotypes were determined by quantitative polymerase chain reaction method. Serum MnSOD activity is determined by the ELISA method. Results: Genotype frequencies for MnSOD gene Ala16Val polymorphism were identified as C/C (Homozigot wild type), C/T (Heterozigot), T/T (Homozigot polymorph type) genotypes in the KAH group, respectively 20.9%, 41.9%, 37.2 and 15.5%, 51.7%, 32.8 per cent in the non-KAH group. MnSOD activities in the whole study group were found to have low MnSOD activity when compared to the MnSOD gene Ala16Val genotypes, CC genotype carriers were high, TT genotype carriers had low MnSOD activity. In patients with no coronary artery disease, MnSOD Ala16Val polymorphism has a significant effect on the fat-free body mass (p=0.01) and the fat mass (p=0.05). While the eating habits with fat-rich foods in HA patients with the heterosygot genotype of Ala16Val polymorphism were lower compared to other genotypes, the HA patients with the homosygot polymorphic genotype were found to adopt protein-free eating habits compared to other genotypes. Result: When all the study group was evaluated, MnSOD Ala16Val had no significant relationship between genotypes and eating habits, while it had no effect on the fat-free body mass.

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