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DELTA-AMINOLEVULINIC ACID DEHYDRATASE (ALAD) GENETIC POLYMORPHISM IN TURKISH POPULATION
2001
Journal:  
Ankara Üniversitesi Eczacılık Fakültesi Dergisi
Author:  
DOI:  
10.1501/Eczfak_0000000353
Abstract:

Delta-aminolevulinic acid dehydratase (ALAD) is an enzyme involved in the heme biosynthetic pathway. ALAD is inhibited by lead. This enzyme is polymorphic with two alleles, ALAD1 and ALAD2. These alleles differ by a single base pair change, a guanine to cytosine transversion of coding nucleotide 177. This base substitution permits to apply a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay for genotyping the ALAD gene. In this study, polymorphism of the ALAD gene has been investigated in a Turkish population using PCR-RFLP method. The frequency of the ALAD1 was found to be 0.81. The comparison of this result with other population samples shows that significant difference exists among ethnic groups in ALAD gene polymorphism

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Ankara Üniversitesi Eczacılık Fakültesi Dergisi

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 833
Cite : 494
Details
Ankara Üniversitesi Eczacılık Fakültesi Dergisi