Abstract:

Objective:  Malignant melanoma of the larynx is an uncommon tumor type that can be seen as a primary tumor or as a metastasis from a cutaneous primary lesion.  Morphological appearances of this tumor are readily confused with the other types of laryngeal cancers.  A new case of primary laryngeal malignant melanoma has been presented in this case report . Case: The patient was a 54-year-old man without any clinical evidence of other cutaneous malignant melanocytic lesions. Microscopically, polygonal-epithelioid tumor cells containing cytoplasmic and nuclear melanin were located under the mucosal squamous epithelial cells. Atypical mitotic figures were also present. Ulceration and disruption of the epithelium weren’t observed. Immunohistochemical studies were positive for S100, HMB-45, Melan-A and vimentin while it was negative for cytokeratin. Based on findings this diagnosis was established.

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