Özet:

Netrines, a family of protein similar to lamine, were initially defined by their roles in embryonic axonal guidance. These molecules with chemotropic characteristics behave like a two-functional regulator of the neuron migration. Researchers have shown that, regardless of their role in the central nervous system, netrin-1 plays a role in the development and formation of tissues other than the nerve in relation to the cardiovascular area, netrin-1 promotes angiogenesis and accelerates atherosclerosis, protects the heart against damage to ischemic-reperfusion and reduces the size of infarction.These findings make netrin-1 an important therapeutic target, especially because it has contradictory effects in many physiological and patofysiological processes. In this collection, the functions of netrin-1 signals during cardiovascular diseases, including atherosclerosis, angiogenesis and ischemic reperfusion repair, were reviewed.

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