Özet:

The aim of the work.  Study the nomenclature of emulsifiers and antimicrobial preservatives, used in modern semi-solid drugs, data analysis of scientific literature on the development of new drugs emulsion type.  Materials and Methods.  Methods of information retrieval and analysis of literature data are used.  Results and Discussion.  To date, a large number of dermatological preparations are medicines of emulsion type with a high content of the water phase – these are semi-solid preparations for the skin and medicinal cosmetic creams. In the manufacture of emulsion preparation, it is important to select the auxiliary substances, in particular emulsifiers and antimicrobial preservatives, which are mainly surfactants by their structure, and often cause side reactions.  Practically all synthetic surface-active substances can remove all fatty products from the body surface, in particular a thin protective film that forms sebaceous and sweat glands of the skin.  Therefore, it is promising to use biogenic surfactants as emulsifiers and preservatives.  The study of the range of emulsifiers and antimicrobial preservatives used in semi-solid emulsion registered in the State Register of Medicinal Products of Ukraine was conducted.  As a result of the study, it was found that polysorbates are mainly used as emulsifiers of the 1st kind and cetostearyl alcohol and lanolin as emulsifiers of the 2nd kind in emulsion medicines.  Conclusions.  Considering that synthetic surfactants can cause significant adverse reactions and are strong allergens, it is relevant to study biogenic surfactants as promising emulsifiers and antimicrobial preservatives, to establish their emulsion and preservation ability, which will facilitate the expansion of the range of excipients for emulsion medicines and cosmetics.

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