Özet:

The renewal of the liver after various damage is a necessary event for the maintenance of its important functions such as metabolism and detoxification. The regeneration event is very well identified histologically. What is interesting is cytokines and growth factors that control the different stages of liver regeneration. The vascular endotelial growth factor (VEGF) increases the microvascular passivity and is a specific mitochondria for endotelial cells and is believed to play an important role in angiogenesis. In the presented study, the expression of VEGF and receptors (fltl / fms, flkl / KDR and flt4) was immunochemically studied. There were 10 rats in the study. Positive immune reaction for VEGF and its receptors was determined in the endothelial and flat muscle cells of the hepatocytes in the muscle and blood vessels. However, the immune reaction of flt1/fms in hepatocytes around the vein center was quite strong compared to VEGF, flk1/KDR and flt4. As a result, VEGF and receptors (flt1 / fms, flk1 / KDR and flt4) show that they play important roles in the physiological changes of the rats' liver.

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