Özet:

Purpose: This study is planned to determine whether the parameters of the full blood count and the scores based on the full blood count will be used as a diagnostic bio-indicator in the newborn sepsis. Methods: This retrospective-planned study included 70 newborn patients diagnosed with sepsis (Group 1) and 65 healthy newborns (Group 2) in the same age, gender, birth weight and week of birth. Demographic data, blood culture results, clinical and laboratory findings were obtained from medical records. Scores based on the full blood count, such as neutrophil/lenfocyt ratio (NLO), trombocyt ratio/lenfocyt ratio (TLO), eozinophil/lenfocyt ratio (ELO), basophil/lenfocyt ratio (BLO) and monocyt/lenfocyt ratio (MLO), were calculated by the division of the number of neutrophils, trombocytes, eozinophils, basophils and monocytes respectively into the number of lymphocytes. Results: There was no difference between groups in terms of demographic characteristics such as age, gender, birth rate, form of birth and week of pregnancy (p>0,05). The C-reactive protein levels were significantly increased in the newborn sepsis group (p<0,001). While the number of neutrophils in the newborn sepsis group was significantly high (p<0,001), the number of lymphocytes, thrombocytes, eosinophils and monocytes was significantly low (respectively; p=0,001, p<0,001, p<0,001, p=0,005). There was no difference between the groups in terms of hemoglobin, hematocrit, erythrosite, leukocyte, basophyll, average erythrosite volume (MCV), average thrombocyte volume (MPV), erythrosite distribution width (RDW) and thrombocyte distribution width (PDW), BLO, MLO and TLO (p>0,05). While the NLO was significantly high in the newborn sepsis group (2,19±1,39 vs 1,44±1,07, p<0,001), the ELO was significantly low (0,08±0,07 vs 0,09±0,05, p=0,007). While the number of ELOs, lymphocytes, thrombocytes, eosinofil and monocytes showed a negative correlation (p<0,05). According to the results of the ROC curve analysis, the numbers of CRP, NLO, ELO, neutrophils, lymphocytes, thrombocytes, eosinophils and monocytes were determined as meaningful parameters for the diagnosis of neonatal sepsis. Equivalent for CRP was 6,09 mg/L (sensitivity %88,6, specificity %100, AUC:0,964, p<0,001), 1,01 for NLO (sensitivity %78,57, specificity %63,08, AUC:0,727, p<0,001), 0,079 for ELO (sensitivity %64,29 specificity %56,92, AUC:0,634, p=0,007), 4,66x109/L (sensitivity %68,57, specificity %61,54, AUC:0,683, p<0,001), 4,33x109/L for lymphocytes (sensitivity %65,71, integrity %60, AUC:0,668, p<0,001), 0,079 for ELO (sensitivity %64,29 specificity %56, AUC:06,669, p<0,001) and 0,09% for AUC (sensitivity %66,69,09,09,09,09,09,09,0 The result: Although their sensitivity and peculiarities are lower than CRP; NLOs, ELOs, neutrophils, lymphocytes, thrombocytes, eosinophils and monocytes can be considered as helpful data that contribute to the diagnosis of newborn sepsis. Specifically, NLOs with high sensitivity and specificity appear to be a useful full blood count parameter for the diagnosis of neonatal sepsis.

Anahtar Kelimeler: