Abstract:

Purpose: The purpose of the study is to investigate the effect of Nerium oleander (NO) distillate on oxidative damage and other side effects caused by the doxorubic. Tools and Methods: NO leaves were liophilized by distillation after gathering. The study divided 28 rats into 4 groups: Control, Doksorubin (3 mg/kg, a peritonium in two days, 6 applications), NO (1 mg/kg/day, oral) and Doksorubin (3 mg/kg, a peritonium in two days, 6 applications) + NO (1 mg/kg/day, oral), and the applications were performed for 11 days. 24 hours after the last application, blood was taken from the hearts of the rat under anesthesia and was immediately overwhelmed. It was also homogenized by taking the heart, liver and kidney organs. The levels of organ tiobarburic acid derivative reactive substances (TBARS) were determined by ELISA, serum biochemical values by autoanalyzer and full blood values in the blood cell counting device. Results: The kidney TBARS of the Doksorubisin group was determined higher than the NO distillate group (P<0.05) while the heart TBARS of the Doksorubisin group was determined lower than the Doksorubisin + NO distillate group (P<0.05). It was found that the use of Doksorubin reduces the number of blood cells, hemoglobin and hematocrit levels according to the control group (P<0.05), and that the use of Doksorubin + NO distillate only increases the hematocrit value. Doksorubicin is used to reduce the levels of albumin according to the control group (P<0) with serum total protein. 05), Doksorubisin + NO distillate application was determined to increase the levels of nitrogen in the blood urine by aspartate aminotransferase according to the control group (P<0.05) and to reduce the values of total protein, albumin and creatine (P<0.05). Recommendation: The level of NO distillate used in the current research may be stated that it has no clear effect on the prevention of the unwanted effects caused by its dosoruby.

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