Özet:

Objective Tumors of women with breast cancer show clinical and biological differences depending on the hormonal changes that develop with age. Therefore, in this study, we compared the radiologic, and clinicopathological features of breast cancer patient’s < 40 age and ≥55 age. Material and Method The files of a total of 759 patients, including 92 patients under 40 aged, and 322 patients 55 aged and over who were operated on for breast cancer over a 10-year period in three centres were retrospectively reviewed and Estrojen Reseptor (ER), Progesteron Reseptor (PR), Human epidermal growth factor receptor 2 (HER2), Lymphovascular invasion (LVI) status, presence of axillary lymph node metastasis (ALNM), multifocality, presence of Ductal Carsinoma İnsitu (DCIS) or Lobular Carsinoma İnsitu (LCIS), tumor size, tumor histopathological type, grade, and score were recorded. Results In patients under the age of 40, the tumor is less localized in the upper-inner and lower-inner quadrants of the breast, multifocality is more common, most of them have dense breast structure, the histological grade of the tumor is higher, LVI and LNM are more common. It was found that they had ER receptor positivity and higher Ki-67 proliferation index (p<0.001, p<0.001, p<0.001, p<0.001, p=0.021, p=0.039, p=0.001 and p<0.001, respectively). It was observed that the multifocality and density of breast tissue were lower in tumors in patients under 55 years of age (p = 0.002, p <0.001, respectively). Luminal B and TN were more common among molecular subtypes in patients under 40 years of age, while luminal A subtype was more common in patients over 55 years of age (p<0.001, p=0.001, respectively). Conclusion Clinicopathological differences between <40 aged, and 55 aged and over patients were confirmed. Adverse prognostic factors for breast cancer at the age of under 40 patients were revealed.

Anahtar Kelimeler: