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Diyabetik Sıçanların Beyin Dokusu ve Plazmasında RF ve ELF Radyasyonun Oksidatif Stres Üzerindeki Etkileri
2023
Journal:  
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi
Author:  
Abstract:

Amaç: Teknolojinin ilerlemesi ve endüstrileşme ile birlikte hayatımızın hemen hemen her alanında yer alan RF ve ELF radyasyona maruziyet gittikçe artmaktadır. Çalışmadaki amacımız RF ve ELF radyasyonun diyabetik ve diyabetik olmayan sıçanların beyin doku ve plazmasında oksidatif strese etkilerini araştırmaktır. Yöntem: Deney grupları K (Kontrol), S (Sham), ELF (ELF manyetik alan maruziyeti), RF (RF Radyasyon maruziyeti), ELF+RF (ELF manyetik alan ve RF radyasyon maruziyeti), D-K (Diyabet Kontrol), D-S (Diyabet Sham), D-ELF (Diyabet ELF manyetik alan maruziyeti), D-RF (Diyabet RF radyasyon maruziyeti), D-ELF+RF (Diyabet ELF manyetik alan ve RF radyasyon maruziyeti) olarak tasarlandı. Deneysel diyabet modeli tek doz 65mg/kg Streptozotosin (STZ) ile oluşturuldu. RF radyasyon (2100 MHz) ve ELF (50 Hz) manyetik alan 1 ay boyunca, 20 dakika/gün, 5 gün/hafta olmak üzere uygulandı. Beyin doku ve plazmada toplam nitrik oksit (NOx), malondilaldehit (MDA) ve plazmada toplam sülfidril grupları (RSH) / dokuda glutatyon (GSH) düzeyleri bakıldı. Bulgular: RF + ELF radyasyon maruziyeti, diyabetik olan ve olmayan sıçanların plazma ve beyin dokusunda NOx ve MDA düzeylerinde artışa neden oldu (p<0,05). RF ve RF + ELF radyasyonuna maruz kalma diyabetik olmayan sıçanlarda plazmada RSH / dokuda GSH düzeylerini azalttı (p<0,05). Sonuç: En belirgin etki, diyabetik grupta RF + ELF radyasyon maruziyeti ile görüldü.

Keywords:

Effects Of Rf and Elf Radiation On Oxidative Stress Of Brain Tissue and Plasma Of Diabetic Rats
2023
Author:  
Abstract:

Objective: Exposure to Radio Frequency (RF) and Extremely Low Frequency (ELF) radiation is increasing steadily with the progress of technology and industrialization. The aim of this study was to investigate whether RF and ELF radiation are oxidative stress effects in the plasma and brain tissue of diabetic and non-diabetic rats. Methods: Experiment groups were designed as follows; C (control), S (sham), ELF (ELF radiation exposure), RF (RF radiation exposure), ELF+RF (ELF and RF radiation exposure), D-C (Diabetic Control), D-S (Diabetic Sham), D-ELF (Diabetic ELF), D-RF (Diabetic RF), D-ELF+RF (Diabetic ELF+RF). The experimental diabetes model was induced with a single dose of 65mg/kg streptozotocin (STZ). 2100 MHz RF and 50 Hz ELF radiation groups exposed for 1 month. Total nitric oxide (NOx), malondialdehyde (MDA) and total sulfhydryl groups (RSH) / glutathione (GSH) levels were measured in plasma and brain tissue. Results: RF + ELF radiation exposure caused an increase in NOx and MDA levels in plasma and brain tissue of diabetic and non-diabetic rats (p<0.05). Exposure to RF and RF + ELF radiation caused a decrease in plasma RSH / tissue GSH levels in non-diabetic rats (p<0.05). Conclusion: The most prominent effect was seen in the diabetic group with RF + ELF radiation exposure.

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Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

Metrics
Article : 279
Cite : 562
Kocaeli Üniversitesi Sağlık Bilimleri Dergisi