Özet:

Objective: This study was aimed to assess the risk of serious adverse outcomes in patients with hypertension related to the Coronavirus Disease 2019 (COVID-19). Subject and method: The case and control study was conducted based on sampling 905 male and female patients aged 25-75 years. Socio-demographics, clinical, lab tests and comorbidities data were obtained and evaluated within the scope of this research. Results: A significant difference was observed between hypertensive versus normotensive regarding age groups, BMI, cigarette smoking, nargile and alcohol use, Metabolic Syndrome (ATP III), Metabolic Syndrome (IDF), thyroid, Chronic Obstructive Pulmonary Disease (COPD), infection, stroke Coronary Heart Failure (CHF), malignite, diabetes, cerebrovascular disease and vitamin D Levels. Significant differences were detected between hypertensive versus normotensive subjects also regarding BMI, hemoglobin, vitamin D, vitamin B12, calcium, HDL, fasting blood glucose, creatinine, Total Cholesterol, HDL, triglyceride, uric acid, ferritin, Fe, TSH, systolic and diastolic blood pressure, WBC, CK, CK-MB, D-dimer, Hematocrit, Neutrophil, Lymphocyte, Platelet, Creatinine, AST, ALT, CRP, Procalcitonin, respectively. Importantly, the multivariate stepwise regression analysis estimated that total cholesterol (p < 0.001), Systolic BP (p < 0.001), procalcitonin (p < 0.001), calcium (p < 0.001), ferritin (p < 0.001), creatine kinase (p < 0.001), vitamin D (p = 0.004) , smoking (Yes) (p = 0.005) and BMI (p = 0.012) can be regarded as risk predictors of the hypertension among COVID-19 patients. Conclusion: The presented work highlighted the presence of comorbid symptoms in roughly one-third of the population in the course of the COVID-19 pandemic. Additionally, substantial differences in clinical biochemistry properties were detected between hypertensive and normotensive individuals among COVID-19 positive patients. Consequently, this report provides novel insights into clinical characteristics and impact of hypertension in COVID-19.

Anahtar Kelimeler: