Özet:

Stem cells are sensitive to stress because of their properties and functions. The presence of growth factors, cytokines, oxidative stress and mechanical stresses stimulate cell division and differentiation. Several signaling pathways that regulate the self-renewal and differentiation of stem cells are stress response pathways. Stem cells have a long life span and have the potential to divide. These properties cause transformation on cells, create specific stress responses such as apoptosis and senescence.mAging is an important source of stress for stem cells. Repetitive divisions, epigenetic irregularities, mutations and telomere erosions that occur in stem cells can cause cumulative effects on cells. In addition, chronic inflammation and oxidative stress cause impairment of systemic signals of the stem cell niche. In addition to generating serious damage to biological macromolecules, oxidative stress can cause genomic instability and cellular senescence by affecting cell proliferation. There are two different types of stress in stem cells: external stress caused by environmental factors that cause a potentially harmful change in a biological system, and internal stress that causes the accumulation of waste products during normal metabolism and the formation of reactive metabolites. Internal and external stresses that occur in stem cells cause different damages according to tissue-specific stem cell types. In this review; stress, factors causing stress and some therapeutic agents used against stress were taken in stem cells. Keywords: Stem cells, stress, therapeutic, agents

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