Abstract:

The purpose of this study is Coenzyme Q10? The experimental colite model induced with acetic acid in mice is the study of the effect on mucosa, goblet cell intensity and closely connected proteins. In the study, 24 female 10-week Wistar albino rats were used and divided into three groups: Control group (n=4), Colite group (n=10) and Colite+Coenzyme Q10 group (n=10). Experience of 4 percent. Created with acetic acid. One day after cholite induction, the colite+coenzyme Q10 group was administered with coenzyme Q10 (30 mg/kg/day) for 10 days. At the end of the treatment procedure, the testimony of the animals was carried out. A macroscopic assessment of the colon tissues was made. Colon cuts painted with the triple paint of Masson and Alsian blue, microscopic scoring and goblet cell intensity; Okludin, Zonula Okludens-1 and Klaudin-1 immunohistochemical analyses also assessed the closely linked proteins. Results: The macroscopic and microscopic scores of the colon tissues of the colite group showed statistically significant increase compared to the control group (p<0.05). In the colite+coenzyme Q10 group, the macroscopic and histopathological damage has been significantly reduced (p<0.05), and the proportion of the coenzyme Q10 and the Alsian blue positive field has been statistically increased (p<0) compared to the colite group. 05) and the related goblet noted that the increased cell intensity, which is important in the integrity of the mucous barrier, also increased in immunoreactivity. Recommendation: As a result, Coenzyme Q10 has shown a positive effect on histopathological changes on the colon tissue in the colite model induced by acetic acid and on the protein of close connection. However, more detailed and advanced molecular techniques supported various experimental and clinical research on the protective effects of coenzyme Q10 against ulcerative colitis is considered necessary.

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