Abstract:

Purpose: The study was aimed at investigating the effectiveness of thyrozole on cardiotoxicity created by docsorubisin. Method: The rats were divided into 4 groups and 8 rats were in each group. Group 1 and group 2 were given 1 ml of serum physiological, group 3 and group 4 were given 20 mg/kg of thyrozole. Serum physiological and thyrozole applications have been used by the oral gage method. In addition, on the 12th day of the group 2 and group 4, the dose of 15 mg/kg and single dose of intraperitoneal doxorubin were administered. On the 14th day of the trial, serum and tissue samples were taken from the rat under anesthesia and later exhausted. Serum creatine kinase MB and creatine kinase activities have been analyzed. The heart tissues were removed and the histopathological and oxidative stress parameters were analysed in these tissues. The activity of the enzyme catalase and glutathone peroxydase with malondialdehitis and reduced glutathone levels was spectrophotometrically determined. The findings: A rise in the heart tissue malondial dehydrate (p<0.05), caused by the pre-treatment of thyrozole, has been shown to prevent the low levels of glutathion and the decrease in the activity of the enzyme glutathion peroxidase and to suppress the oxidative stress caused by the thyrozole in the heart tissue. There were no differences between the groups in terms of the activity of the cardiovascular catalase enzyme. Due to the reduction of oxidative damage to the heart, the serum creatine kinase MB and creatine kinase activity (p<0.05) were significantly reduced. It has also been found that thyrozole pre-treatment prevents the histopathological lesions caused by the docsoruby in the heart tissue. Recommendation: It is believed that the application of tirosol can reduce the cardiotoxicity caused by the dosoruby.