Abstract:

Insulin resistance, defined as disruption in the response of the target cell to normal levels of circulation, is a common pathological condition. The potential effects of cytokines on insulin sensitivity have been subject to intense research. The aim of this study is to explore the connection between glucose metabolism abnormalities such as insulin resistance in patients with rheumatoid arthritis and serum interleukin 1α levels. The study included 36 patients with rheumatoid arthritis with disease activity in different degrees (22 women and 14 men, average age: 51.5 ±17.1 years (21-80 years), average VKI: 27.1 ±5.0 kg/m2) and 20 healthy controls with similar characteristics as age, gender, VKI. The hunger serum levels of IL-1α and insulin were measured. The sensitivity of insulin was calculated by the HOMA method. In patients with rheumatoid arthritis, the levels of hunger serum insulin, HOMA scores and serum IL-1α levels were significantly increased (14.7±6.7, 8.7±1.9 μIU/ml, p<0.001 and 3.3±1.5, 1.9±0.5, p<0.001 and 18.2±13.3, 13.0±2.4 pg/ml, p<0.01 respectively). In all cases there was a connection between the levels of hunger insulin, HOMA-IR, IL-1α. In our study, we observed that in patients with rheumatoid arthritis, the regulation of IL-1α was deteriorated, there was a significant link between IL-1α and insulin sensitivity.

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