Özet:

Amaç The aim of the study was to determine the presence and degree of endothelial injury by measuring plasma concentrations of cellular fibronectin (cFn) and circulating nitrate and total nitrite levels, end-products of Nitric Oxide, in pregnancies complicated by preeclampsia. Yöntem   Circulating cellular fibronectin, nitrate and nitrite levels were compared between preeclamptic (n=20) and normotensive women (n=22). Two groups were similar at patients age, gestational age. Stored plasma, which had been obtained in ihe third trimester before labor, was assayed for cellular fibronectin by means of a sensitive and specific enzyme immunoassay, and serum nitrate, total nitrite levels measured by enzymatic Greiss reaction Bulgular The values of cFn were significantly higher (47.4 ± 27.9 mg/dl) in the third trimester in the group of women with preeclampsia, as compared to normals (26.8 ± 12.2 mg/dl). Sera from women with preeclampsia had significantly lower nitrate concentrations (24.16 ±3.12 vs 30.77 ±3.41, p<.0.05) compared with healthy pregnant women respectively controls, however, there were no significant differences at the serum total nitrite levels between two groups. Sonuç Pregnancies complicated by preeclampsia had significantly higher plasma cellular fibronectin concentrations, and significantly lower serum nitrate levels than did control pregnancies. We speculate that the combination of a deficiency of serum nitrate and an increase in cFN may directly or indirectly initiate the vast majority of physiological and serological changes associated with preeclampsia.

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