Abstract:

Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30% of non-Hodgkin lymphoma (NHL) in adults. In our study, the clinicopathological features of patients with DLBCL were evaluated retrospectively. Methods: The study included 43 patients with the diagnosis of DLBCL between 2009–2016. Clinical and histopathological features of the patients were collected from the archive of our hospital. Results: The average age of the patients was 62.5 (23-86). Twenty four of them (55.8%) were male and 19 (44.2%) were female. Twenty five patients (58.1%) had B symptoms. Early stage (I and II) disease was seen in 21 (48.8%) patients, while advanced stage (III and 1V) disease was seen in 22 (51.2%) patients. Bone marrow involvement was present in 5 (11.6%) patients. Nodal involvement was 39.5% and extranodal involvement was present in 60.5% of patients. The most commen involved node was cervical lymph node and the most involved extranodal site was gastrointestinal system an especially stomach. Immunohistochemically, BCL2 and BCL6, which had prognostic significance, were expressed as 46.5% (n = 20) and 27.9% (n = 12) respectively. A significant relationship was found between Bcl6 protein expression and gender (p <0.001, almost all female patients) and extranodal involvement (p = 0.009). The patients were in a low risk group with a rate of 58.1% and a high risk of 41.9% according to the international prognostic index (IPI). Of 43 patients, 27 were deceased. The average survival rate was 37.2%. DISCUSSION AND CONCLUSION: In this study, there was no correlation between the histopathological features and mean life, but an inverse relationship was found with IPI score. In our study, clinical and immunophenotypic features and their prognostic parameters of DBBHLs were emphasized.

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