Özet:

Objective: To clarify its role on insulin resistance in pregnant women with GDM and by measuring the level of YKL-40 in maternal serum. Materials and Methods: 40 GDM and 40 healthy term pregnant women followed in Cerrahpaşa Medical Faculty, Department of Obstetrics and Gynecology between June 2012 and June 2013 were included in the study. Demographic and clinical parameters of pregnant women were obtained from patient files. Fasting glucose, HbA1C, fasting insulin and YKL-40 levels were measured in these pregnant women. The HOMA-IR value was calculated. The parameters of GDM and healthy pregnant women were compared. The relationship between serum YKL-40 level and insulin resistance parameters was investigated. Results: There was no statistical difference between GDM and healthy pregnant women in terms of age, systolic and diastolic blood pressure, gestational week, birth weight, leukocyte count and fasting glucose level (p > 0.05 for all). BMI, HbA1c, fasting insulin level, HOMA-IR value and YKL-40 level were found to be statistically significantly higher in pregnant women with GDM (31.8 ± 4.3, 28.1 ± 2.4, p:0.001 5.86 ± 1.85, 5.11 ± 0.25, respectively). , p:0.001, 12.74 ± 6.52, 7.44 ± 2.12, p:0.001, 3.12 ± 1.94, 1.81 ± 0.48, p:0.001). Serum YKL-40 level was positively correlated with BMI, HbaA1C, fasting insulin, and HOMA-IR value (respectively, r:0.507, p:0.001 r:0.668, p:0.001 r:0.556, p:0.001 r: 0.379, p:0.009). Conclusion: It was determined that serum YKL-40 level increased in pregnant women with GDM and this level was positively correlated with insulin resistance parameters.

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