Abstract:

INTRODUCTION: It is known that in patients with ischemic heart disease, QT dispersion (QTd), predicts ventricular arrhytmia and sudden cardiac death. It is also acknowledged that major coronary risk factors such as smoking, diabetes mellitus, hypertension prolong QTd. In this study, possible relationship between isolated hyperlipidemia and QT dispersion was investigated. METHODS: 76 patients (39 females, 37 males; mean age 46±9.89) with isolated hyperlipidemia and 62 healthy subjects (30 females, 32 males, mean age 43.56±9.96) were included in the study. Resting 12 derivation ECGs recorded at 25 mm/sec. of all patients and subjects were recorded. Corrected QTd (QTcd) values were obtained according to Bazett’s Formula and then corrected QT dispersion (QTcd) was accepted as the difference between the longest and shortest QT values. RESULTS: QTcmax and QTcd values of the study group were significantly higher than those of the control group (p<0.001). In addition, QTcd values of isolated high LDL cholesterol and triglyceride subgroups were significantly higher than those of the control group (p<0.001). DISCUSSION AND CONCLUSION: Isolated hyperlipidemia may have a direct effect on the QT intervals and repolarization phase of the ventricular myocardium.

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