Aim: Spontaneous rupture of the spleen is a rare, life-threatening condition with a high mortality if not intervened in a timely manner. In this case report, we wanted to present a patient with hereditary spherocytosis and spontaneous splenic rupture. Case Report: In the first evaluation of a 20-year-old male patient who presented to the emergency service with the complaints of nausea-vomiting and abdominal pain after alcohol intake, his general condition was good and he was conscious and cooperative oriented. Vital signs; Blood Pressure: 110/70 mmHg, Pulse: 100 beats / min, Respiratory Rate: 14 / min, Fever: 36,5 ° C. Hereditary spherocytosis was present in the medical history of the patient. Symptomatic treatment and fluid replacement were initiated primarily. During the observation, due to the aggravation of abdominal pain and the development of widespread sensitivity, pain in the left shoulder, dizziness and worsening in vital signs, advanced imaging examinations were performed. Contrast-enhanced abdominal computed tomography revealed rupture in the superior posterior part of the spleen and diffuse free peritoneal fluid in the abdomen. The patient, who underwent emergency laparotomy and splenectomy by the general surgery department, was discharged on the 8th day of the follow-up. Conclusion: Spontaneous rupture of the spleen has a high mortality. Emergency physicians should evaluate patients who have consumed alcohol with a good history and physical examination. On the other hand, spontaneous rupture of the spleen should be kept in mind in patients who present with acute onset of nontraumatic abdominal pain and who have a history of splenomegaly, especially hereditary spherocytosis.
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