Özet:

The three major diphenolic, hydrobhobic orange coloured compounds derived from the rhizome of Curcuma longa Linn. (turmeric) of Zingiberaceae family, namely diferuloylmethane, demethoxycurcumin and bisdemethoxycurcumin has been exhibited several pharmacological efficacies both in preclinical and clinical studies through its anti-inflammatory, anti-microbial, anticancer and anti-Alzheimer properties. Furthermore, these curcuminoids were also showed hepatoprotective, nephroprotective, neuroprotective, cardioprotective, hypoglycaemic activities. Researchers were also observed the antioxidant properties of these novel compounds in a significant level. Therefore, all the curcuminoids were considered as an important bioactive molecule in the natural product market and herbal industry. Despite being a robust pharmacologically active agent, all the three curcuminoids were exhibited very poor solubility in water and therefore the systemic bioavailability were also very low, which attributed very poor absorption, faster metabolism and systemic elimination after oral administration. Consequently, its therapeutic actions were also diminished in a significant percentage. In this scenario researchers have been designed and developed several nanotechnological delivery system for curcuminoids to overcome this limitation. Here, in this article, we have summarized the various methods of nanocurcumin including polymeric nanoparticles and micelles, liposomes, cyclodextrins, solid dispersions, peptide carriers, lipid nanoparticles and emulsions. 

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