Abstract:

Purpose: With this study, the acute liver damage that occurs with renal ischemic reperfusion in rats and the effect of p-cumic acid (p-CA) on this oxidate damage were studied. Tools and Methods: 12-16 weeks 200-250 gr thirty-two Wistar Albino sex female rats were classified as groups applied sham (S), renal ischemic-reperfusion (R-IR), R-IR with 50 mg/kg p-CA (p-CA 50) and R-IR with 100 mg/kg p-CA (p-CA 100). The back area of rats in other groups except Sham was opened and after the right nefrectomy was made, the left renal artery was clamped and p-CA therapy was applied with the reperfusion protocol. After the test protocol was completed, the levels of total antioxidant status (TAS), total oxidant status (TOS), superoxid dismutase (SOD), malondialdehitis (MDA) and myeloperoxidase (MPO) in the lungs tissue were measured by spectrophotometric methods. The oxidative stress index (OSI) is calculated. Results: In the R-IR group, TOS, MDA, MPO and OSI increased significantly, while TAS and SOD levels fell (p<0.001). p-CA groups observed an increase in TAS and SOD levels and a decrease in TOS, MDA and MPO values (p<0.001). Results: With the achieved results, renal ischemic reaction has been demonstrated by biochemical methods that reduce acute lungs damage through p-CA treatment.

Keywords: