Özet:

Purpose: Hypofysic adenomas are seen with severe morbidity due to local press effect and hormone emissions. The purpose of the treatment is to eliminate this press effect, to normalize hormone hypersecretion, to maintain normal front and rear hypofysic functions, and to eliminate the possibility of recurrence. In our study, we aimed at examining the hormone values taken in the preoperative, postoperative early period and third month of 70 patients with the injury that occurs in the hypofysic lounge and transphenoidal microchirurgical treatment, in terms of endocrinological remissions. The findings: The frequently applied complaints were headaches, galactors, vision disorders, and acromegalic symptoms. The tumor size is 45 of 70 incidents (64.28%) in macroadenoma, 25 (35. 7% was detected as a microadenoma. 11 of the cases were endocrine inactive adenoma, 25 were prolactinoma, 17 were GH hormone secretion adenoma, 10 were ACTH secretion adenoma, 6 were GH and prolactin secretion adenoma, 1 was ACTH and prolactinoma secretion adenoma. The endocrine cur rate in all patients operated by TSC method: 76.4% in acromegaly cases, 66.6% in acromegaly and prolactinomal cases, 90% in cushing cases, 100% in cushing cases and 100% in prolactinomal cases, and 80% in prolactinomal cases. Consequently, transphenoidal microchirurgy has been found as a safe and effective method for preserving the normal pityite gland while the tumor is removed with a lower mobidity and mortality rate. Keywords: hypofysic adenoma; transphenoidal microchirurgical; endocrine cur ABSTRACT Objective: Hypophyseal adenomas causes very high morbidity because of local mass effect and hypophyseal hormones secretion. Treatment goals are hormone secretion normalization, removing local mass effect, protection of both anterior and posterior hypophyseal functions and prevent recurrence. Meterial and Methods: In our study, we examined pre-operative, post-operative early days and three months after surgery hormonal values in 70 patients operated via transsphenoidal surgery to evaluate endocrinological remission. Patients complaints were mostly headaches, galactorrhea, vision problems and acromegaly. Results: Hypophyseal lesion you were macroadenoma in 45 (%64.28) patients, microadenoma in 25 (%35. 7 of patients. We evaluated 11 cases have endocrine inactive adenomas, 25 cases have prolactinomas, 17 cases have growth hormone secreting adenomas, 10 cases have ACTH secreting adenomas, 6 cases have GH and prolactin secreting adenomas and 1 case has ACTH and prolactin secreting adenoma. Endocrinological remission rates in patients operated by transsphenoidal surgery were 76.4 % in acromegaly cases, 66.6 % in acromegaly and prolactinoma cases, 90 % in Cushing cases, 100 % in Cushing and prolactinoma cases and 80 % in prolactinoma cases. Conclusion: At the end, transsphenoidal hypophyseal microsurgery was effective and reliable technique because of low morbidity and mortality rates and protection the normal pituitary function after surgery. Key words: Hypophyseal adenoma; Transsphenoidal hypophyseal microsurgery; Endocrinologic remission