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Amaç: Obezite kronik inflamasyona neden olmaktadır. Bariatrik cerrahi sonrası kilo kaybı ile kronik hastalıklar ve inflamasyonun gerilediği bilinmektedir. Bu çalışmanın amacı laparoskopik sleeve gastrektomi sonrası erken dönem metabolik ve inflamatuar değişimlerin değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Morbid obezite nedeniyle opere edilen hastaların demografik özellikleri ile birlikte operasyon öncesi ve sonrası vücut kitle indeksi, bel çevresi, kan lökosit sayısı, CRP, AST, ALT, GGT, düzeyleri değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen 82 morbid obez hastanın 21 (%25,6) erkek, 61 (%74,4) kadındı. Ortalama yaşı 33,7±9,6 (18-64), ortalama BMI 42,9±6,1 kg/m2 (32,3-59,4), bel çevresi 126,6±17,7 cm (103-153) idi. Preop ve postop ortalama değerler arasında anlamlı fark saptanmamakla birlikte lökosit, ALT, AST ve GGT ortalama değerlerinin postoperatif erken dönemde daha düşük olduğu saptanmıştır. Sonuç: Obezitenin sebep olduğu kronik inflamasyon durumu diyabet, insülin direnci ve kanser ile ilişkilidir. Cerrahi olarak indüklenen kilo kaybı ve anatomik değişiklikler kronik inflamasyonda iyileşme için önemli bir rol oynayabilir.
Obesity causes chronic inflammation. It is known that weight loss after bariatric surgery with chronic diseases and inflammation is reduced. The aim of this study is to evaluate early metabolic and inflammatory changes after laparoscopic sleeve gastrectomy. Tools and methods: with the demographic characteristics of patients operated due to morbid obesity, pre- and postoperative body mass index, back circle, blood leukocytes number, CRP, AST, ALT, GGT, levels have been evaluated. Results: Of the 82 morbid obesity patients involved in the study, 21 (25.6%) were men and 61 (74.4%) women. The average age was 33,7±9,6 (18-64), the average BMI was 42,9±6,1 kg/m2 (32,3-59,4), the back circle was 126,6±17,7 cm (103-153). Although there is no significant difference between the Preop and Postos average values, the lococyte, ALT, AST and GGT average values have been found to be lower in the early postoperative period. The result: the chronic inflammatory condition caused by obesity is associated with diabetes, insulin resistance and cancer. Surgery-induced weight loss and anatomical changes can play an important role in recovery in chronic inflammation.
Purpose: Obesity is known to improve chronic inflammatory status. It is known that chronic diseases and inflammation regress with weight loss after bariatric surgery. The aim of this study is to evaluate early metabolic and inflammatory changes after laparoscopic sleeve gastrectomy. Materials and methods: The demographic features of the patients who were operated for morbid obesity were evaluated before and after the operation, body mass index, waist circumference, blood leukocyte count, CRP, AST, ALT, GGT levels. Results: Eighty-two patients were included in this study. 21 (25.6%) patients were male and 61 (74.4%) were female. Mean age was 33.7±9.6 (18-64), mean BMI was 42.9±6.1 kg/m2 (32.3-59.4), waist circumference was 126.6±17.7 cm (103-153). Although no significant difference was found between preop and postop mean values, leukocyte, ALT, AST and GGT mean values were found to be lower in the early postop postoperative period. Conclusion: Chronic inflammation caused by obesity is associated with diabetes, insulin resistance and cancer. Bariatric surgery induced weight loss and anatomical changes can play an important role in healing chronic inflammation.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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