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Amaç: Çalışma radyografik ve non-radyografik aksiyal spondiloartritli nr-aksSpA hastalarda nötrofil/lenfosit oranı NLR , platelet/lenfosit oranı PLR , eritrosit dağılım genişliği RDW ve ortalama trombosit hacmi MPV değerlerinin karşılaştırılması amacıyla planlanmıştır.Gereç ve Yöntemler: Kırk radyografik aksSpA [Ankilozan spondilitli AS ] hastası, 40 nr-aksSpA hastası ve 40 sağlıklı kontrol çalışmaya dahil edildi. Bath Ankilozan Spondilit Hastalık Aktivitesi İndeksi BASDAI , C-reaktif protein CRP , eritrosit sedimentasyon hızı ESH , NLR, PLR, RDW ve MPV değerleri hasta kayıtlarından elde edildi.Bulgular: CRP, ESH, RDW, NLR ve PLR değerleri hastalık şiddeti arttıkça arttı. Bu parametrelerin hepsi AS’li hastalarda kontrol grubuna göre anlamlı olarak yüksekti, ancak nr-aksSpA’lı hastalarla kontrol grubu arasındaki farklar istatistiksel olarak anlamlı değildi. RDW ve PLR değerleri AS’li hastalarda nr-aksSpA hastalarına göre anlamlı olarak daha yüksekti. MPV hastalık şiddeti arttıkça azaldı. AS’li hastalarda hastalık aktivitesiyle PLR ve MPV değerleri arasında korelasyon vardı. AS’li hastalarda NLR ve PLR değerleri CRP ile pozitif korelasyon gösterdi. Nr-aksSpA hastalarında NLR CRP ile, PLR ESH ile pozitif korelasyon gösterdi.Sonuç: RDW ve PLR aksSpA’lı hastalarda hastalık şiddetini değerlendirmek için basit, ucuz ve güvenilir potansiyel birer parametre olarak kullanılabilir. PLR ve MPV değerleri AS hastalık aktivitesinin değerlendirilmesinde, NLR ve PLR ise hem AS hem de nr-aksSpA hastalarında inflamasyonun değerlendirilmesinde kullanılabilir
Purpose: The study is planned to compare the values of the neutrophil/lenfocyt ratio NLR, platelet/lenfocyt ratio PLR, erythrosite distribution width RDW and average thrombocyt volume MPV in patients with radiographic and non-radiographic action spondylarthritis nr-aksSpA.The study is planned to compare the values of the MPV ratio in patients with radiographic and non-radiographic action spondylarthritis nr-aksSpA.The study includes 40 patients with nr-aksSpA and 40 patients with healthy control. Bath Ankylosan Spondylitis Disease Activity Index BASDAI, C-reactive protein CRP, erythrosite sedimentation speed ESH, NLR, PLR, RDW and MPV values were obtained from patient records.The values: CRP, ESH, RDW, NLR and PLR values increased as the severity of the disease increased. All of these parameters were significantly higher compared to the control group in patients with AS, but the differences between patients with nr-aksSpA and the control group were not statistically significant. RDW and PLR values were significantly higher in patients with AS compared to nr-aksSpA patients. The severity of the MPV disease has decreased. In AS patients, there was a correlation between the PLR and MPV values with the disease activity. In AS patients, NLR and PLR values showed a positive correlation with CRP. With NLR CRP in Nr-aksSpA patients, PLR has shown a positive correlation with ESH.Result: RDW and PLR can be used as a simple, cheap and reliable potential one-parameter to assess the severity of the disease in patients with aksSpA. PLR and MPV values can be used in the assessment of AS disease activity, while NLR and PLR can be used in the assessment of inflammation in both AS and nr-aksSpA patients.
Objective: This study was planned to compare the neutrophil/lymphocyte ratio NLR , platelet/lymphocyte ratio PLR , erythrocyte distribution width RDW , and mean platelet volume MPV in patients with radiographic and non-radiographic axial spondyloarthritis nr-axSpA .Material and Methods: Forty radiographic axSpA patients [Ankylosing spondylitis AS ], 40 nr-axSpA patients, and 40 healthy controls were included in the study. Bath Ankylosing Spondylitis Disease Activity Index BASDAI , C-reactive protein CRP , erythrocyte sedimentation rate ESR , NLR, PLR, RDW, and MPV values were obtained from the patient records.Results: CRP, ESR, RDW, NLR, and PLR values increased as the disease severity increased. All of these parameters were significantly higher in patients with AS compared to the control group However, the differences between the patients with nr-axSpA and the control group were not statistically significant. RDW and PLR were significantly higher in patients with AS compared to the nr-axSpA patients. MPV decreased as the disease severity increased. There was a correlation between disease activity and PLR and MPV in AS patients. NLR and PLR values were positively correlated with CRP in AS patients. In nr-axSpA patients, NLR was positively correlated with CRP, and PLR was positively correlated with ESR. Conclusion: RDW and PLR can be used as simple, inexpensive and reliable potential parameters to evaluate disease severity in patients with axSpA. PLR and MPV values can be used to assess AS disease activity, while NLR and PLR can be used to assess inflammation in both AS and nr-axSpA patients.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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