Özet:

Abstract The aim of the study is to investigate the relationship between free oxygen radicals and vanadium in vanadium cytotoxicity. For this purpose erythrocyte copper zinc superoxide dismutase (CuZn-SOD) erythrocyte and plasma selenium dependent glutathione peroxidase (SeGSH-Px) enzyme activities, erythrocyte thiobarbituric acid reactive substances (TBARS) levels, erythrocyte and plasma vanadium levels were measured in Sprague Dawley rats fed with 0.15mgV/ml in tap water for the period of 15 days. And also water, food consumption and weight loss were followed during the test. Control rats were fed with normal tap water. Erythrocyte CuZn-SOD (175.4±61.40 U/ml) and plasma SeGSH-Px (0.50±0.05 U/ml) activities were significantly lower than that of control group (519.90±67.84 and 0.63±0.09 U/ml respectively) (p Özet Bu çalismanin amaci vanadyum (V) sitotoksisitesinde serbest oksijen radikalleri ve V arasindaki iliskiyi incelemektir. Bu amaçla 15 gün süreyle mililitrede 0.15 mg V içeren içme sulariyla beslenen Sprague Dawley cinsi disi siçanlarda eritrosit bakir-çinko süperoksit dismutaz (CuZn-SOD), eritrosit tiobarbitürik asit reaktif ürünleri (TBARS), eritrosit ve plazma V seviyeleri ölçüldü. Ayni zamanda yiyecek ve su tüketimleriyle kilo kayiplari da deney boyunca takip edildi. Kontrol grubu siçanlara normal çesme suyu verildi. Eritrosit CuZn-SOD (175.4±61.40 U/ml) ve plazma SeGSH-Px (0.50±0.05 U/ml) aktiviteleri kontrol grubundaki degerlerden (sirasiyla 519.90±67.84 and 0.63±0.09 U/ml) anlamli olarak daha düsüktü (sirasiyla p

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