Özet:

The aim of the work. To develop the composition and technology of gamma-aminobutyric acid with thiotriazoline tablets. Materials and Methods. We used gamma-aminobutyric acid (Sigma-Aldrich, USA); thiotriazoline (State Enterprise “Chemical Reagents Plant” of the Scientific and Technological Complex of the Institute of Single Crystals of the National Academy of Sciences of Ukraine), excipients of domestic and foreign production. GABA with thiotriazoline tablets were prepared by wet granulation. We compressed the tablets using a laboratory tablet press 6000S (Belarus) with a punch diameter of 10 mm and controlled their pharmaco-technological properties. Results and Discussions. A third-order Latin square was used to study the three factors. The influence of the nature of excipients on the tablets appearance, the uniformity of mass, the friability, disintegration time and resistance to crushing were studied. Based on the results of experimental studies, the analysis of variance of experimental data was carried out and conclusions were made about the influence of the studied factors on the quality indicators of GABA with thiotriazoline tablets. Conclusions. Result of the study, the influence of three excipient factors on the appearance, the uniformity of mass, the friability, disintegration time and resistance to crushing of tablets was studied. Analysis of variance of the results allowed to choose the better excipients (MCC 301, 3 % solution of MC 100, magnesium stearate), which provide the pharmacopoeial pharmaco-technological requirements for tablet dosage forms.

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