Özet:

The level of IgE is an important parameter relating to asthma playing a santral role in the phsyopathology of the disease. Also eosinophils are believed to have an important role in the pathogenesis of asthma. In the studies, the level of IgE and blood eosinophil level have been found to be higher than the control group and COPD. In this study, it was aimed to investigate the kinetics of the levels of IgE and blood eosinophil between the asthmatics and healthy people and the factors effecting these and also the correlation between the severity of the asthma and levels of IgE and peripheric blood eosinophil. Total number of 100 cases applied to our polyclinic between October 2002-May 2003 were included to the study. The mean age was found as 30.3±9.2 for the group of patients and 30.5±12.6 for the control group. Comparing the IgE and eosinophil levels, the group of patients’s ratio of eosinophil was found as % 4.8±4.2 and the control group’s was as % 2.1±1.0 (p<0.005). Also comparing the ratio of IgE levels between these 2 groups showed that although IgE level of the group of patients was as 378.8±377.7, it was found as 78.5± 62.5 for the control group (p<0.05). In the group of patients, 13 mild intermittent, 21 mild persistent and 16 moderate persistent cases were detected. Comparing the 3 asthmatic groups with the control group, the difference occured for the 2 parameters were significant statistically (p<0.05). Statistical significance was detected between the IgE levels of the mild persistent and moderate persistent asthma (p<0.05), but no significant difference was detected between the other groups (p>0.05). IgE and eosinophil levels play an important role in the diagnosis and differential diagnosis of asthma but their role to determine the severity of the disease is controversial. More detailed studies are needed to understand the value of these parameters in determining the severity and prognosis of the disease.

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