Abstract:

Objective: In moderate and severe mitral regurgitation MSMR , left ventricular systolic dysfunction develops in time. We aimed to investigate the effect of mitral regurgitation on left ventricular mechanics as assessed with 2D strain echocardiography. We also sought to explore the correlation between BNP and severity of MR and also between BNP and LV mechanics.Material and Methods: Twenty four asymptomatic patients with organic MSMR were included. Left ventricular global longitudinal strain LV-GLS , global circumferential strain and global radial strain were calculated and serum BNP was measured. Patients were divided into two groups according to their BNP value [≥140 pg/ml group 1 and < 140 pg/ml group 2 ].Results: Demographic data were similar in both groups. Group 1 had higher mitral E and A valve velocities 0.915±0.297 vs. 1.2±0.337, p=0.023 and 0.634±0.191 vs. 0.862±0.255, p=0,035 respectively . There was a significant difference in GLS values between group 1 and 2 -20.159 ± 0.386 vs. -15.35±0.912, p

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