Özet:

This study studied the protective effects of resveratrol and dialyl dysulfitine against the damage caused by cadmium on male fertility, which has significant environmental pollutants and harmful effects on tissues. The experiment used Wistar albino rat and created 5 groups (A: control, B1: CdCl2, B2: RES + CdCl2, B3: DDS + CdCl2, B4: RES + DDS + CdCl2). To evaluate histological changes, testicular tissues were painted with Hematoxylene and Eozin, and modified Johnsen scores were made. The observed apoptosis in groups was evaluated by TUNEL method and active kaspas-3 immunohistochemistry. According to the findings we obtained, in the B1 group, it was observed that kadmium caused damage to seminifer tubules, stopped spermogenesis and induced apoptosis in germs. Modified Johnsen scores showed a significant decrease in the B1 group, while the apoptotic index results showed a significant increase. Compared to B1 and B2, B3 and B4, there was no significant difference between B1 and B2 in modified Johnsen scores, while there was a significant increase in B3 and B4 groups. In addition, there was no significant difference in the apoptotic index results in the B2 group, while a significant reduction in the B3 and B4 groups was observed. As a result, information on the role of resveratrol and dialyl disulphitin in the suppression of acute damage caused by cadmium in the mushroom was revealed. The prescribed dose of resveratrol was not effective in suppressing this acute damage while dialyl disulfit and resveratrol were found effective in prevention of damage. According to our literary analysis, this study is the first study that shows the protective effects of dialyl disulphitin against testicular damage caused by the kadmium.

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