Özet:

Free oxygen radicals, produced endogenically through body metabolism play a role in the pathogenesis of hypertension. They have destructive effects unless they are detoxified. Recent studies have shown their role in cardiovascular diseases. This study included 45 essential hypertension patients (25 males, 20 females) and 45 healthy controls (22 males, 23 females). The levels of serum malondialdehyde (MDA) and erythrocyte's superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (CAT) enzymes were all determined and statistically assessed. Erythrocytes levels of SOD, GSH-PX and CAT were statistically decreased (p<0.05) whereas serum level of MDA was statistically increased (p<0. The data demonstrated that the levels of antioxidant enzyme systems in hypertensive patients which have protective properties against the damaging effects of free radicals were reduced and therefore such patients are faced with a serious oxidative stress. It was concluded that interventions intended to regulate there antioxidant enzyme systems might be effective in preventing hypertension

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