Özet:

Though gastric carcinomas are more common in eastern countries, they are the second most common tumours causing death world wide. Prognostic factors are very important for deciding treatment modalities and the determination of recurrences and metastasis. In our study microscopic types of adenocarcinomas according to Lauren’s classification (intestinal/diffuse/mixed type), grade of the tumour, presence of lymph node metastasis (L1), absence of lymph node metastasis (L0), depth of tumoural invasion according to TNM classification (pT1, pT2, pT3), perineural and perivascular tumoural infiltration, presence of necrosis and inflammatory reactions are evaluated as prognostic factors. Parrafin blocked sections of tumoural tissues are stained with anti p53 immunohistochemically. Nuclear staining with anti p53 is accepted as immunopositive. Immunonegative tissues are evaluated as P0, immunopositivity in less than 25 % of tumour is evaluated as P1(+), tumours with 25 % to 50 % immunopositivity are P2 (++) and tumours with more than 50 % immunopositivity are P3 (+++). 15 of the cases (33.3 %) are diagnosed as P0, 8 of the cases (17.7 %) are diagnosed as P1, 7 of the cases (15.5 %) are P2 and l5 of the cases (33.3 %) are diagnosed as P3. As a result when p53 immunoreactivity is compared with the prognostic factors, we found that only perivascular tumoural invasion (p<0.05) and perineural tumoural invasion (r=0.155, p= 0.045) are correlated with p53 immunopositivity and these results are statistically significant.

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