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Henoch-Schönlein purpurası çocuklarda sık görülen ve küçük çaplı damarları tutan bir vaskülittir. Cilt, eklem, gastrointestinal sistem ve renal tutulum ile kendini gösterir. Genellikle böbrek tutulum dışında kendi kendine iyileşebilen bir hastalıktır. Henoch-Schönlein purpuralı çocukların %30-50’sinde böbrek tutulumu görülür. Renal tutulum için risk faktörleri arasında 7 yaş üstü olmak, şiddetli gastrointestinal bulguların olması ve purpuranın uzun sürmesi gözlenmiştir. Böbrek tutulumunda mikroskopik ve/veya makroskopik hematüri, proteinüri, daha seyrek olarak nefrotik sendrom, akut nefritik sendrom, hipertansiyon ve akut böbrek yetmezliğine kadar uzanan değişik klinik şekiller görülebilir. Henoch-Schönlein purpura nefriti ve IgA nefropatisi glomerüllerde glikozile IgA1’in depolanması ile ilgili hastalıklardır. Hastalık renal tutulum, tedaviye bağlı olarak sekelsiz iyileşebileceği gibi, ağır kresentik glomerülonefrit ve kronik böbrek yetmezliği ile sonuçlanabilir. Bu nedenle renal tutulum hastalığın prognozunu belirleyen en önemli bulgudur. Bu derlemede Henoch-Schönlein purpurasının renal tutulumu ve tedavisi tartışılmıştır.
Henoch-Schönlein purple is a vasculitis that is common in children and holds small-diameter veins. It manifests itself with the skin, joints, the gastrointestinal system and renal holding. The kidney is often a disease that can heal itself apart from holding. In 30-50% of children with Henoch-Schönlein purple, kidney constipation occurs. Risk factors for renal retention were observed to be over 7 years of age, having severe gastrointestinal symptoms and prolonged purpura. Different clinical forms can be seen in the kidney holding, ranging from microscopic and/or macroscopic hematuria, proteinuria, more frequently nephrotic syndrome, acute nephrotic syndrome, hypertension and acute kidney failure. Henoch-Schönlein purpura nefritis and IgA nefropathy are diseases associated with the storage of glycosile IgA1 in glomerules. The disease can result in severe crentic glomerulonefritis and chronic renal insufficiency, as it can be healed unaccessively depending on treatment. Therefore, renal attitude is an important conclusion that determines the prognosis of the disease. This collection discussed the renal constipation and treatment of Henoch-Schönlein purpures.
Henoch-Schönlein purpura is a vasculitis commonly seen in children and holding small diameter vessels. It manifests with skin, joint, gastrointestinal system and renal involvement. It is usually a self-healing disease other than renal involvement. Kidney involvement is frequently seen in 30-50% children with Henoch-Schönlein purpura. Risk factors for renal involvement were over 7 years of age, severe gastrointestinal findings, and long duration of purpura. Renal involvement can be seen in various clinical forms ranging from microscopic and/or macroscopic hematuria, proteinuria, rarely nephrotic syndrome, acute nephritic syndrome, hypertension and acute renal failure. Henoch-Schönlein purpura nephritis and IgA nephropathy are diseases related to the storage of glycosylated IgAl in glomeruli. Disease renal involvement may improve without sequelae due to treatment, as well as severe crescentic glomerulonephritis and chronic renal failure. Therefore, renal involvement is the most important finding that determines the prognosis of the disease. In this review, renal involvement and treatment of Henoch-Schönlein purpura nefritis has been discussed.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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