Abstract:

Purpose: The clinical importance of thrombocytes in liver diseases associated with hepatitis B virus (HBV) has been shown in many studies. It has also been that inflammation in the liver is associated with lipid metabolism disorder. The aim of this study is to investigate whether trombocytes and biochemical parameters in HBV-DNA positive and HBV-DNA negative patients contribute to the follow-up of treatment of hepatitis B patients. In this study, 54 HBV-DNA positive, 54 HBV-DNA negative patients infected with hepatitis B from the Tokat Gaziosmanpaşa University Medical School Hospital Microbiology Laboratory were evaluated as retrospective. Aspartate aminotransferase (AST), alanin aminotransferase (ALT), low-intensity lipoprotein (LDL) parameters are determined by the spectrophotometric method of the COBAS 6000 (Roche Dianostic, France), the levels of trombocytes (PLT), the average volume of trombocytes (MPV) and the trombocytes-big cell ratio (P-LCR) parameters are determined by the Sysmex XN 1000 (Sysmex, Kobe, Japan) hemogram device. In the group comparison, the student t-test and one-way ANOVA test were used. The value of P<0.05 is statically meaningful. Results: In this study, in patients with both HBV-DNA positive and HBV-DNA negative (chronic hepatitis B patients) a statistically significant increase in AST, ALT, LDL, MPV and P-LCR levels according to the control group was found but a statistically significant decrease in PLT levels (P<0.05). The results we obtain indicate that the AST, ALT, LDL, PLT, MPV and P-LCR parameters are easy to work and low-cost parameters, which can be used in the treatment of the disease if necessary. P-LCR has been considered as part of the trombocytes index parameters that can contribute to the clinic in the tracking of hepatitis B disease.

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