Özet:

Aim: Multiple Sclerozis (MS) is characterized by chronic inlammation and demyelination in central nervous system. Although the etiology of MS is unknown, both genetic and enviromental contributions to the pathogenesis are inferred from epidemiologic studies. As with many autoimmune diseases, the genetic susceptibilitiy to MS is determined by genes encoded within the HLA class II region. Tha aim of the study is to find out the distribution of Human Leukocyte Antigen (HLA) Class II DQ antigens and whether any particular HLA II DQ antigens are truly necessary for the development of relapsing-remitting type Multiple Sclerosis (RRMS). Methods: In this rectospective study, we investigated HLA class II DQ antigens in 135 RRMS patients who were 18-61 years of age and 891 healthy controls using microlymphocytotoxicity method. The results were compared and relative risk was calculated by Odds Ratio (OR) method. Results: DQ1, DQ2, DQ3, DQ4, DQ5, DQ6, DQ7, DQ8 and DQ9 were found as positive in 35, 21, 9, 9, 14, 48, 56, 9 and in 2 patients respectively. DQ6 was found very high in patients with MS (OR=30.17; 15.86-58.05) and it was considered as the most striking result in the RRMS patients. The frequency of DQ1 was determined as 25.9% in the patient group and 41% in the control group. DQl has been determined to have a protective role in RRMS (OR=0.51; 0.32-0. 76). Conclusions: Our results have shown that, while HLA DQ1 is protective, HLA DQ4, DQ6 and DQ8 significantly increase the risk of MS development.

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