Özet:

The purpose of this present study was to design and develop a Buspirone hydrochloride loaded matrix type transdermal drug delivery system (TDDS) with four natural gum polymers such as Guar gum, Gellan gum, Xanthan gum, Karaya gum. A total of twelve batch of matrix patches were formulated with above stated polymers and other excipient like Glycerin, Propylene glycol (PG), Polyethylene glycol (PEG) as plasticizer. These all batches were characterized by evaluation parameters which including drug content, flatness, thickness, uniformity of weight, folding endurance, moisture content, moisture uptake and to determine the amount of Buspirone hydrochloride present in the matrix of patches in vitro dissolution study of all twelve formulations were performed. Fourier transform infrared (FTIR) technique and Differential Scanning Colorimetry (DSC) carried out to determine interaction between Buspirone HCl and excipients which are present in patch. Permeation study of patch of Buspirone HCl was performed in Franz's diffusion cell to evaluate In-vitro skin permeation and it was found that batch G3 shows 98.89% permeability. After evaluating all batches and based on results which are obtained characterization and In-Vitro dissolution it was concluded that patches containing natural polymers are not showing any interaction and better release study.

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