Özet:

Objective: Epicardial adipose tissue is the local energy source for the contraction activity of the heart. However, chemerin is a novel chemoattractant adipocytokine released from adipose tissue. Chemerin and its receptor have been detected in epicardial adipose tissue and cardiomyocytes. The relationship between chemerin and cardiovascular diseases such as hypertension, diabetes, obesity, dyslipidemia, coronary heart disease, and atrial fibrillation has been demonstrated in previous studies. As the causes of supraventricular tachycardia (SVT), which is one of the many types of arrhythmias, are still clearly unknown, SVT is still an important source of life-threatening morbidity. In the present study, the purpose was to determine possible relations between plasma chemerin level, which had relation with cardiovascular diseases, with SVT. Methods: A total of 62 patients, who were diagnosed as having SVT by the cardiology clinic, and 27 controls were included in this study. Hematological and serum biochemistry parameters were analyzed. The plasma chemerin concentrations were measured with the ELISA technique. Results: Chemerin levels were higher at statistically significant levels in SVT group compared to the control group (p<0.001). The heart rate per minute was significantly lower in the control group compared to the patient group (p<0.001). The Pearson’s correlation analysis revealed that there was a positive correlation between chemerin levels in plasma and average heart rate. Also, neutrophil/lymphocyte ratio was significantly higher in SVT group than in the control group (1.95±26.53 vs. 1.42±0.7, p<0.01). Conclusion: This study showed for the first time that plasma chemerin level was elevated in SVT. In addition, this study determined a positive correlation between high plasma chemerin concentration and heart rate. Determining and controlling the circulating level of chemerin, which is associated with cardiovascular diseases, inflammation, metabolic syndrome and many other diseases, may be important in SVT.

Anahtar Kelimeler: