Özet:

Type 2 diabetes mellitus is a metabolic disease characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or deficiency. The signal path of the Wnt/?-catin plays a role in all physiological processes. Any defect on the way will cause the development of diabetes. The aim of this study is to determine the effect of grape nuts extract (GSE) on body weight, blood sugar and gen expression in type 2 diabetic rats. Tool and Method: The rats were divided into five groups: Diabetes Control, Diabetes Control and Treatment Groups (100, 200, 400 mg/kg GSE). Rats in diabetes and treatment groups were given a high-fat diet and a low-dose streptozotine (35 mg/kg). During the test, the body weight of the rats was recorded weekly. The water-solved extract was applied through the gage for four weeks, and the study used samples of liver, pancreas and blood taken from animals at the end of the treatment. Results: The effect of GSE treatment on diabetes-related overall weight loss was minimal, and the doses of 100 and 400 mg/kg of GSE were observed to lower blood sugar (p<0,05). There was no statistically significant difference between the groups in terms of liver tissue (p>0,05) and pancreas tissue (p<0,05) according to the genetic expression results. Recommendation: According to the findings obtained, wheat grains can be hopeful in the treatment of diabetes.

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