Özet:

Aim: In developing countries, Rotavirus Gastroenteritis (RG) is even now one of the most common causes of death and morbidity. As a result, clinicians must be extremely vigilant in detecting the presence and severity of RG. The goal of this study was to identify predictors of RG severity by analyzing complete blood counts, including neutrophil-to-lymphocyte ratio (NLR), mean platelet volume-to-platelet volume (MPV/P) platelet-to-lymphocyte ratio (PLR). Material and Method: Data were obtained retrospectively from medical records of 456 children diagnosed with RG and age-matched healthy children from University of Health and Sciences, Ankara Atatürk Sanatorium Training and Research Hospital between January 2019 and December 2021. The Vesikari Score was used to categorize disease severity as severe or mild. Variables’ prognostic effects on disease severity were equated across groups. Results: The study included 456 children with RG. Two hundred thirty two of them were severe 126 males median age: 1.24 (0.41-2.36 years), 224 of them non-severe 126 males median age 1.52 (1.01-2.84 years). The median length of hospitalization was 5 (4-7) days for the severe group and 2 (0-3) days for the non-severe group (p<0.001). Neutrophils, monocyte, platelet, red cell distribution width, NLR, and PLR levels in RG patients were statistically significantly higher than in the control group, while hemoglobin, platelet distribution width, MPV, and MPV/P levels were lower (p<0.001). The area under the operating characteristic curve (AUC) for NLR, and MPV/P for severe disease was calculated as (0.556 and 0.709, respectively), and was all statistically significant (p<0.001). However, PLR was not found statistically significant in ROC analysis (p>0.001). Conclusion: NLR was increased and MPV/P was decreased with the increase in severity of Rotavirus Gastroenteritis. NLR and MPV/P were useful for providing additional severity stratification in RG.

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